Matteo Orsini (died probably on 18 August 1340) was an Italian Dominican and Cardinal.
He entered the Dominican Order, completed the full course of theology, obtained the Degree of Master, and taught theology at Paris, Florence, and Rome. He won distinction by his zeal for the spread of the order, and was appointed provincial of the Roman province in 1322.
In this capacity he became a member of the embassy deputed by the Romans to invite Pope John XXII to transfer his residence back from Avignon to Rome. On 20 October 1326, the pope named him Bishop of Girgenti, in Sicily, but shortly after (15 June 1327) transferred him to the archiepiscopal see of Siponto, (Manfredonia, Southern Italy), made him Cardinal priest of Ss. Giovanni e Paolo on 18 December 1327, and Cardinal-Bishop of Sabina on 18 December 1338.
He continued in various ways to promote the welfare of the Dominican Order, richly endowing the Convent of St. Dominic in Bologna.